Harnessing the power of a story offers many opportunities in the field of public health with informing disaster management and response being one of them. A recent article published in the Journal of Visual Languages and Computing highlights how visual storyboards can benefit communication in emergency situations.
Exercise Can Change Your DNA
For my last post (wow, has it really been 10 weeks already?) I’ve decided to plunge into the sciency stuff more than I have in my previous posts. The article I’m reporting on contains very complicated cell/molecular biology material, but I wanted to really challenge myself to help a broad audience of readers understand something at a deeper level while I still have wonderful and insightful mentors who will provide feedback. I get really excited about the inner mechanisms of cell biology, especially when it relates to physical activity, and hopefully I can spread a little bit of that joy with my readers.
It’s a widely accepted fact that exercise is good for us. It burns calories, helps us lose weight, and increases muscle mass. When our muscles contract during physical activity, it changes the metabolic activity, increasing the efficiency in which it uses sugar and fats for energy. New research published in Cell Metabolism discovered just how these changes occur: exercise changes your DNA. More specifically, exercise modifies the DNA in your muscles by removing methyl groups, and this increases production of proteins that support muscle growth and the breakdown of fats and sugar. Before I go any further, let’s back up a little bit so we can understand what’s happening in the cell. Continue reading
Progress on the Liver Cancer Front
Nearly everyone knows someone with cancer. There’s a lot of awareness around cancers of the breast and lung, but liver cancer (hepatocellular carcinoma) doesn’t see much airtime. Despite its lack of fame, hepatocellular carcinoma is the fifth most common cancer in the world, and was responsible for 695,000 deaths in 2008 alone. Liver cancer is aggressive. Five years after diagnosis, the relative survival rate is only 14%, largely because we just don’t know how to treat it. Currently, patients with hepatocellular carcinoma only have one treatment option: surgery and a somewhat effective chemotherapy designed for kidney cancer. But progress is being made in this field. Researchers have discovered a new molecule that shows promise for additional chemotherapy treatments.
The research uses oncogene addiction, a technique in which the disruption of one cellular protein leads to the death of the cancer cell. In this case, that protein is LSF. LSF is found in all human cells and organs, but is more abundant in tumor cells. The high levels of LSF in liver cancer cells lead to the growth of the cancerous tumors. Scientists used to think it was impossible to create a drug targeting LSF, however, this compound changed their minds.
Factor quinolinone inhibitor 1 (FQI1) is a compound made from lead that has been shown to target the protein LSF in mice, and human patient tissue samples. By inhibiting the protein, it was able to kill liver cancer cells and prevent tumor growth. Many chemotherapy drugs are able to kill cancer cells, but the problem is they also kill healthy cells. What makes this finding so important is that it killed only the cancer cells, leaving the surrounding non-cancerous cells untouched.
This finding has set the groundwork for a chemotherapy option specific to hepatocellular carcinoma that only kills cancerous cells. This drug has the potential to save many lives and increase the survival rate of a devastating disease affecting people across the globe.
Reference:
Grant, T.J., Bishop, J.A., Christadore, L.M., Barot, G., Chin, H.G., Woodson, S., Kavouris, J., Siddiq, A., Gredler, R., Shen, X., Sherman, J., Meehan, T., Fitzgerald, K., Pradhan, S., Briggs, L.A., Andrews, W.H., Sarkar, D., Schaus, S.E., and Hansen, U. (2012). Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. PNAS, 109 (11), 1-6. Doi:10.1073/pnas.1121601109
Health Literacy and Mortality Outcomes
I struggled a few weeks ago while completing a homework assignment for my Tailored Health Communications class. We were assigned to write a short health promotion message using plain language and an eighth grade reading level to demonstrate the difficulty of writing to a health illiterate population. It turns out that that portion of the population is substantial—the Institute of Medicine reports that 90 million Americans struggle with reading and comprehending health information. Health literacy goes far beyond simply reading because it requires complex analysis and the comprehension of terms and definitions that are often completely foreign to the reader. Those at the highest risk for health illiteracy include older adults over age 65, along with low-income and minority populations. What does this mean for health outcomes?
A recent study in the British Medical Journal analyzed the association between low functional health literacy and mortality in older adults in England. Over 7000 older adults aged 52 and over participated in the longitudinal cohort study, which used data from the 2004 English Longitudinal Study of Ageing. Each participant completed a health literacy functionality test that measured the level of health literacy by analyzing participants’ ability to comprehend written instructions for taking an aspirin tablet. They were asked to read instructions on a bottle label and were questioned by trained interviewers regarding medication instructions. Based on participants’ answers, they were given a health literacy score of 0 to 4, based on the number of questions they answered correctly out of 4 questions. Information was also gathered from each participant regarding sex, age, ethnicity, education status, and any pre-existing health conditions. Participants were then tracked through October 2009 for incidence of mortality, including all causes.
25.1% of adults less than 60 years old and 48.4% of adults over 80 years old could not answer all 4 health literacy questions correctly. Adults with no educational qualifications were 4 times more likely to have low health literacy than adults with an educational degree. After adjusting for age and sex, low health literacy was associated with a 75% increased risk of mortality compared to high health literacy. Medium health literacy was associated with a 24% increased risk of mortality compared to high health literacy.
Although this study certainly has limitations such as possible non-response from those with low-literacy in general, it brings the topic of health literacy up for discussion. As we advance in the development of promotional materials and prevention techniques, it is imperative to consider our audience. Health jargon can be difficult to understand and comprehend, and when the stress and fear that are present in many health crisis situations are added, the difficulty can be increased. It is important that health professionals understand and consider this difficulty when interacting with populations at risk for health illiteracy.
Using banana peels to remove metals from polluted water: an aPEELING option
Researchers have found banana peels can remove toxic metals from contaminated water just as well as many expensive laboratory methods. 
Access to Clean Water: A Basic Human Right
A simple turn of the faucet delivers an endless supply of clean and refreshing H2O – in our homes, our offices, and even water used to flush our toilets. Clean drinking water is so readily available that we don’t have to think about where it is coming from or how we are going to get it. Access to clean drinking water is a basic human right that we enjoy on a daily basis. Unfortunately, this right isn’t the reality for millions of people around the world.
The World Health Organization [WHO] estimates that 884 million people world-wide do not have access to clean drinking water. Over half of these individuals live in developing African countries where the consequences of drinking unclean water account for millions of deaths each year. Children, 5 years or younger, are the most vulnerable. In the past, drinking unclean water typically meant high risk to diarrheal diseases caused by bacteria or viruses. Today, drinking unclean water can mean much, much more.
With the ever ongoing and increasing industrial activities in developing nations across the globe, water quality in the most impoverished areas has become increasingly worse. Bacteria and parasites in the waterways of third world countries are no longer the only worries; issues of mining and heavy industry pollution are now adding to the clean water crisis- often times in the form of toxic heavy metals. Exposure to heavy metals [including: lead, mercury, copper, cadmium, chromium] can cause developmental defects in children, neurological effects such as memory loss and behavior changes, chronic diseases like cardiovascular disease, and it may lead to certain types of cancers.
Banana Peels: Removing the Metals
There have been numerous technologies developed to specifically remove metal toxicants from polluted waters- silica, alumina, activated carbon, and resins have all been proven successful… and expensive. While they perform in the high tech laboratories of developed countries, mass manufacturing and distribution of these products in developing nations are expensive and impractical. For rural and remote villages, activated carbon filters are just not a sustainable option for water purification. But, banana peels are.
Using water from Brazil’s Paranhas River and locally grown bananas, researchers at Sao Paublo State University have demonstrated that dried banana peels can successfully remove copper and lead [two common metal pollutants] from contaminated water.
Banana peels contain nitrogen, sulfur, and carboxylic acids; the acids are responsible for the peels’ ability to bind the toxic metals and remove them from the water. Because of the high number of these acids in the peels, not only can banana peels remove the contaminants, but they can do it just as well, and in some cases better, than more expensive technological options. And it’s easy. Without any technical preparation, dried banana peels successfully remove metals.
In areas in South America and sub-Saharan Africa where bananas are a common resource and contaminated water is a common problem, banana peels offer a sustainable and practical way to remove toxic metals from drinking water. By using the same banana peels up to 11 times without replacement, families can successfully minimize their risk of exposure.
Banana peels don’t kill parasites or bacteria, and they aren’t going to protect children from viruses. But, banana peels may offer millions of families around the world the opportunity to drink water free of heavy metals. A basic solution to promote a basic right.
The High Costs of Alcohol-Induced Blackouts in College Students
It only takes a quick drive through a college campus on St. Patrick’s Day to notice that drinking is still one of the favored past times of college students. Throughout college, I have been to my share of parties where drinking games like “wizard staff” and “Edward 40 hands” encourage binge drinking that can often lead to blackouts. As you can imagine, blackouts related to binge drinking can be extremely hazardous to one’s health and even land one in an Emergency Department. Continue reading
Making Soil – Seattle’s model composting program
Recently, a classmate of mine suggested I read about Seattle’s composting program. Having cooked a couple batches myself, as well as having used copious amounts in gardens, I decided to have a look. Seattle’s program provides curb-side pick up to those citizens who have purchased a bin, which run around $6 for a residential size pail. It is a voluntary service, and citizens may choose to retain their compostable materials or put them in the regular trash. Continue reading
Latino farm workers’ health – all eyes on the community
In Michigan, I can enjoy the luxury of going to the grocery store and buying strawberries in the middle of January or buying tomatoes in the spring (or really, any fruit or vegetable at any time of the year). These foods are at my disposal because our food system relies on millions of farm workers (which includes both seasonal and migrant workers, most of whom are from Mexico or of Mexican decent) to grow, harvest, pick, and process the food that I have readily available to me at the grocery store. These workers are legally paid very low wages (median income: $11,000/year) for laborious work, they work long hours, have poor working and living conditions, and often don’t have access to regular healthcare, all of which contribute to various health problems (tuberculosis, malnutrition, scarlet fever, poor dental health, diabetes, hypertension, the list goes on . . .).
Until we’re ready to dramatically change the way we produce food in this country, our reliance on seasonal and migrant workers is unlikely to decrease anytime soon. But are there ways to promote and protect farm workers’ health? Continue reading
Stress: Shrinking Your Brain and Risking Your Health
As spring approaches, so does the end of the semester, and my Google calendar is quickly becoming a blur of colored boxes that signify classes, group project meetings, and florist appointments (because for some reason, I thought it was a good idea to plan a wedding while I was earning my MPH). With a full schedule, impending finals, and a wedding that gets closer by the day, it’s difficult not to feel the pressure. While the things that fill my schedule are unique, I think it’s probably a safe bet that most everyone can identify with a hectic life…and the stress that comes with it.
Stress, despite the unpleasant feelings that often accompany it, is actually meant to be protective, preparing our “fight-or-flight” response in the face of something we perceive as a threat. Unfortunately, extended periods and excessive amounts of stress have effects on our brains and our bodies that are far from healthy. Continue reading
When Prescription Painkillers Kill
Parents are often the target audience of public health messages aimed at prescription drug abuse in teens. Stories like this recent one from Kentucky are common. They urge parents to talk to their kids about drug use, store prescription medications under lock and key and dispose appropriately of unused drugs.
There is reason, of course, to spread this message among parents. National survey data from 2007 suggests that 4.7 million teens (about 1 in 5) have abused a prescription drug at some point.
Earlier this year, the Centers for Disease Control (CDC) published an update on the growing problem of prescription drug overdoses. During 2007 there were approximately 27,000 unintentional drug overdose deaths in the United States. According to the CDC, we are dealing with an epidemic of prescription drug abuse. Prescription painkilles are at the center of this epidemic. Continue reading






